Nested Locations

Is it possible (or even reasonable) to have nested locations? E.g I have several locations defined on my "E:" drive for efficiency reasons (i.e short index times) but I would like to be able to search the entire drive on occasion. Should I make an overarching location of the entire “E” drive for this purpose? Am a newbie so apologies if this is a silly (obvious) question. Thanks in advance for any help.

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